Brent Doiron

  • Professor, Department of Mathematics and Biology

Current Research

Dr. Doiron's research program seeks to identify how single neurons and networks of neurons code information about relevant inputs.

Using a combination of nonlinear systems theory, stochastic differential equations, and information theory I study this problem in the context of somatosensory, auditory, and electrosensory systems. The main goal is to link brain dynamics responsible for coding with putative coding schemes that may be general across many sensory systems. Of particular interest is how correlations and synchrony across a population of thalamic and cortical neurons, including auditory thalamus and cortex, influences the information throughput of sensory processing.

 

Selected Recent Publications

Bittner SR, Williamson RC, Snyder AC, Litwin-Kumar A, Doiron B, Chase SM, Smith MA, Yu BM. Population activity structure of excitatory and inhibitory neurons. PLoS One. 2017 Aug 17;12(8):e0181773. doi: 10.1371/journal.pone.0181773. eCollection 2017. PubMed PMID: 28817581; PubMed Central PMCID: PMC5560553.

Kanashiro T, Ocker GK, Cohen MR, Doiron B. Attentional modulation of neuronal variability in circuit models of cortex. Elife. 2017 Jun 7;6. pii: e23978. doi:10.7554/eLife.23978. PubMed PMID: 28590902; PubMed Central PMCID: PMC5476447.

Williamson RC, Cowley BR, Litwin-Kumar A, Doiron B, Kohn A, Smith MA, Yu BM. Scaling Properties of Dimensionality Reduction for Neural Populations and Network Models. PLoS Comput Biol. 2016 Dec 7;12(12):e1005141. doi:10.1371/journal.pcbi.1005141. eCollection 2016 Dec. PubMed PMID: 27926936; PubMed Central PMCID: PMC5142778.

Rosenbaum R, Smith MA, Kohn A, Rubin JE, Doiron B. The spatial structure of correlated neuronal variability. Nat Neurosci. 2017 Jan;20(1):107-114. doi:10.1038/nn.4433. Epub 2016 Oct 31. PubMed PMID: 27798630; PubMed Central PMCID:PMC5191923.

Litwin-Kumar A, Rosenbaum R, Doiron B. Inhibitory stabilization and visual coding in cortical circuits with multiple interneuron subtypes. J Neurophysiol. 2016 Mar;115(3):1399-409. doi: 10.1152/jn.00732.2015. Epub 2016 Jan 6. PubMed PMID: 26740531; PubMed Central PMCID: PMC4808082.

Litwin-Kumar A, Doiron B. Formation and maintenance of neuronal assemblies through synaptic plasticity. Nat Commun. 2014 Nov 14;5:5319. doi:10.1038/ncomms6319. PubMed PMID: 25395015.

R.Rosenbaum & B. Doiron. Balanced Networks of Spiking Neurons with Spatially Dependent Recurrent Connections. Physical Review X 4, 021039, 2014.

A. Litwin-Kumar & B. Doiron. Slow dynamics and high variability in balanced cortical networks with clustered connections. Nature Neuroscience. 15: 1498-1505, 2012.

B. Doiron, M.J. Chacron, L. Maler, A. Longtin & J. Bastain. Inhibitory feedback required for network oscillatory responses to communication but not prey stimuli. Nature 421:539-543, 2003.

Z.P. Kilpatrick, B. Ermentrout & B. Doiron Optimizing working memory with heterogeneity of recurrent cortical excitation. Journal of Neuroscience, 33: 18999-19011, 2013.

A. Polk, A. Litwin-Kumar & B. Doiron. Correlated neural variability in persistent state networks. Proceedings of the National Academy of Sciences, 109, 6295-6300, 2012.