Dr. Salisbury’s research interests focus on schizophrenia pathophysiology and human electrophysiology. He utilizes electrophysiology and multimodal brain imaging to examine thought disturbance (cognitive-level) and basic auditory processing abnormalities (sensory-level) in psychosis, and specializes in event-related potential recordings in humans. Dr. Salisbury has also collaborated extensively with colleagues using magnetic resonance imaging and functional magnetic resonance imaging methods on a number of research projects.
The goal of Dr. Salisbury’s work is to further understand the neurophysiology of psychosis. Brain activity measures span simple sensory and perceptual processes to complex higher-order cognition. Dysfunction in local circuit activity, reflected in sensory processing deficits, and in long-range distributed cortical processing, reflected in deficits in the interplay between semantic memory neural storage networks and working memory systems that allow adaptive and flexible human behavior in the face of unique current situations, are the main areas of inquiry by which Dr. Salisbury and his team try to detect the underlying brain abnormalities giving rise to psychosis. Understanding of the basic dysfunctions, in turn, will lead to earlier identification, better interventions, and improved outcome in schizophrenia and other psychotic disorders.
Selected Recent Publications
Haigh SM, Matteis M, Coffman BA, Murphy TK, Butera CD, Ward KL, Leiter-McBeth JR, Salisbury DF (2017). Mismatch Negativity to Pitch Pattern Deviants in Schizophrenia. Eur J Neurosci. 2017 Sep;46(6):2229-2239. doi: 10.1111/ejn.13660. Epub 2017 Sep 3
Coffman BA, Haigh SM, Murphy TK, Salisbury DF (2017). Impairment in Mismatch Negativity but not Repetition Suppression in Schizophrenia. Brain Topogr. 2017 Jul;30(4):521-530. doi: 10.1007/s10548-017-0571-1. Epub 2017 May 17.
Salisbury DF, McCathern AG, Coffman BA, Murphy TK, Haigh SM (2017). Complex Mismatch Negativity to Tone Pair Deviants in Long-trem Schizophrenia and in the First-episode Schizophrenia Spectrum. Schizophr Res. 2017 May 12. pii: S0920-9964(17)30253-0. doi: 10.1016/j.schres.2017.04.044. [Epub ahead of print]
Kim M, Lee TH, Kim JH, Hong H, Lee TY, Lee Y, Salisbury DF, Kwon JS (2017). Decomposing P300 into Correlates of Genetic Risk and Current Symptoms in Schizophrenia: An Inter-trial Variability Analysis. Schizohr Res.2017 Apr 8. pii: S0920-9964(17)30188-3. doi: 10.1016/j.schres.2017.04.001. [Epub ahead of print].
Salisbury DF, McCathern AG (2016). Abnormal Complex Auditory Pattern Analysis in Schizophrenia Reflected in an Absent Missing Stimulus Mismatch Negativity. Brain Topogr. 2016 Nov;29(6):867-874. Epub 2016 Aug 12.
Haigh SM, Coffman BA, Murphy TK, Butera CD, Salisbury DF (2016). Abnormal Auditory Pattern Perception in Schizophrenia. Schizophr Res. 2016 Oct;176(2-3):473-479. doi: 10.1016/j.schres.2016.07.007. Epub 2016 Aug 6.
Salisbury DF, Polizzotto NR, Nestor PG, Haigh SM, Koehler J, McCarley RW (2017). Pitch and Duration Mismatch Negativity and Premorbid Intellect in the First Hospitalized Schizophrenia Spectrum. Schizophr Bull. 2017 Mar 1;43(2):407-416. doi: 10.1093/schbul/sbw074.
Haigh SM, Coffman BA, Salisbury DF (2017). Mismatch Negativity in First- Episode Schizophrenia: A Meta- Analysis. Clin EEG Neurosci. 2017 Jan;48(1):3-10. Epub 2016 May 11.
Coffman BA, Haigh SM, Murphy TK, Salisbury DF (2016). Event-related Potentials Demonstrate Deficits in Acoustic Segmentation in Schizophrenia. Schizophr Res. 2016 May;173(1-2):109-15. doi: 10.1016/j.schres.2016.03.012. Epub 2016 Mar 28.
Lee SH, Niznikiewicz M, Asami T, Otsuka T, Salisbury DF, Shenton ME, McCarley RW (2016). Initial and Progressive Gray Matter Abnormalities in Insular Gyrus and Temporal Pole in First-Episode Schizophrenia Contrasted with First-Episode Affective Psychosis. Schizophr Bull. 2016 May;42(3):790-801. doi: 10.1093/schbul/sbv177. Epub 2015 Dec 16.